Immune system - Adaptive immunity ( B cells and T cells)

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This quiz focuses more on Adaptive immunity in the Immune system, questions mostly on the functions of B and T cells.

1

The following are traits of cell-mediated immunity: (i.e T Cells)
- They produce antibodies which attack pathogens, or direct other cells to attack them
- They block infections and eliminate extracellular microbes
- They do not attack pathogens themselves
- Helper cells activate macrophages to kill phagocytosed microbes
2

Which is not true about adaptive immunity:
- Each lymphocyte has receptors for both antigens and for signalling chemical
- Antigens and signalling chemicals must be activated for lymphocyte to begin immune function
- Most lymphocytes are found in bone marrow, thymus gland, lymph nodes and spleen
- Lymphocytes induce pain
3

The following is a lymphocyte route:
- Lymphocytes pour into blood, distribute about the body and make it to lymphatic capillaries. They are transported through lymph nodes and vessels into thoracic & lymphatic ducts into subclavian veins.
- Lymphocytes pour into blood, distribute about the body and make it to venules. They are transported through lymph nodes and vessels into thoracic & lymphatic ducts into subclavian veins.
- Lymphocytes pour into blood, distribute about the body and make it to venules. They are transported through lymph nodes and vessels into thoracic & lymphatic ducts back into lymphatic capillaries.
- Lymphocytes pour into blood, distribute about the body and make it to venules. They are transported through lymph nodes and vessels into thoracic & lymphatic ducts to the heart.
4

Pick up the false statement regarding B cells:
- Naïve B cells (not yet exposed to antigen) are initially produced by bone marrow
- Activation occurs following encounter between naïve B cell and its specific antigen
- Antigen-antibody binding triggers rapid divisions and clones of identical B cells
- An encounter between immunocompetent lymphocyte & invading antigen leads to a cell mediated immune response
- Some identical B cells become effector B cells (plasma cells), others remain in the lymphatic tissue as memory B cells
5

Antibodies:
- Proteins of the family called immunoglobulins
- Immunoglobulins are secreted by B cells (plasma cells) in response to antigens
- Every normal baby is born with huge number of different clones of B cells in bone marrow, lymph nodes and spleen
- All cells in each clone synthesize a specific antibody
- Immunoglobulins consist of M, G, A, E, D
- All are true
- All are false
6

IgG is:
- Synthesised by immature B cells
- Bound to B cell membrane
- Major class of antibodies produced after initial contact with antigen
- All are true
- All are false
7

IgG does not:
- Form the main antibody in primary & especially secondary (subsequent contact) response
- Circulates in blood & tissue spaces
- Cross the placenta - providing natural passive immunity to foetus
- Cause mast cell degranulation and release of histamine
8

Antibody IGA:
- Concentrates in body fluids & secretions
- Protects entrance to GI & respiratory tract
- Prevents attachment of pathogens to epithelial surfaces
- All of the above
- None of the above
9

The precise function of the following Immunoglobulin is unclear, other than it activates the B cell
- IgA
- IgD
- IgE
- IgM
- IgG
10

The following antibody mediates certain allergic reactions, causing mast cell degranulation and release of histamine
- IgA
- IgD
- IgE
- IgM
- IgG
11

Antibodies to not do the following:
- Neutralize bacterial toxins
- Neutralize viruses
- Opsonize bacteria (enhance phagocytosis)
- Suppress T cells
- Activating components of inflammatory response
12

Complements:
- Are found in blood plasma
- Consist of approx 20 protein compounds
- Are inactive enzymes that become activated in a particular sequence to catalyse a series of linked reactions
- Alter their shape to reveal complement binding sites after antigen-antibody binding
- Complement 1 binds to be activated and sets off the cascade of all the complement proteins
- All of the above
- None of the above
13

The following is not a complement function:
- Mast cell degranulation (C3a)
- Opsonisation (C3b)
- Chemotaxis (C5b67)
- Anaphylotoxins (C3a)
- Cell respiration (CAT)
- Increased vascular permeability (C2a, C5a)
- Cell lysis (MAC)
- Recruitment and activation of neutrophils (C5a)

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Immune system - Adaptive immunity ( B cells and T cells)

The following are traits of cell-mediated immunity: (i.e T Cells)

Which is not true about adaptive immunity:

The following is a lymphocyte route:

Pick up the false statement regarding B cells:

Antibodies:

IgG is:

IgG does not:

Antibody IGA:

The precise function of the following Immunoglobulin is unclear, other than it activates the B cell

The following antibody mediates certain allergic reactions, causing mast cell degranulation and release of histamine

Antibodies to not do the following:

Complements:

The following is not a complement function:

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